Anti-Insr T cell receptor (2C), pCDTCR1(TCR-C104Z)
The vector of anti-Insr T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse Insr. The T cells are genetically modified through transduction with a lentiviral vector expressing Insr-specific T cell receptor. And the vector product was designed for the treatment of Type 1 diabetes.
Type 1 diabetes
Insr; Insulin receptor; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.