Anti-Insr T cell receptor (2C), pCDTCR1(TCR-C104Z)

The vector of anti-Insr T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse Insr. The T cells are genetically modified through transduction with a lentiviral vector expressing Insr-specific T cell receptor. And the vector product was designed for the treatment of Type 1 diabetes.


Details


Target
Insr
Target Species
Mouse
Epitope
GNYSFYAL
Format
Non-modified
HLA
H-2Kb
Targeting Diseases
Type 1 diabetes
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
2C
Antibody Host
Mouse

Target


Gene Name
Insulin receptor
Official Symbol
Insr
Gene ID
UniProt ID
Synonyms
Insr; Insulin receptor; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
Introduction
This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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