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Insr

This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.

Associated Disease
  • Type 1 diabetes
  • TCR Vector Products
  • TCR Viral Particles
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    CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
    TCR-C104Z Mouse anti-Insr T cell receptor (2C), pCDTCR1 Mouse 2C Mouse GNYSFYAL H-2Kb Lentiviral   Inquiry
      Datasheet

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