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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Due to their strong similarities to humans across physiologic, developmental, behavioral, immunologic, and genetic levels, non-human primate (NHP) peripheral blood mononuclear cells (PBMCs) are essential models for a wide spectrum of biomedical research. NHP PBMCs can serve to link the translational research between small animal models and humans. Creative Biolabs provides unparalleled access and customized services for researchers to propose cytokine release syndrome (CRS) management solutions. We offer NHP PBMC model products, establishement services as well as further cytokine detection and analysis services for worldwide clients.
PBMCs are a subset of leukocytes, which are integral components of the body's immune system that fight disease. PBMCs consist of a mixture of monocytes and lymphocytes (B cells, T cells, and NK cells) and are isolated from peripheral whole blood via density gradient centrifugation and red blood cell lysis.
PBMCs of NHP are used because of the similarities of these animals to humans in terms of physiology, neuroanatomy, reproduction, cognition, development and social complexity. The close phylogenetic relationship of NHP to humans also makes these animals excellent models for the study of CRS. These similarities between NHP and humans suggest that there is greater validity of the data obtained from primate PBMC models compared to other animal cell models, and experiments conducted using these models might address questions that cannot be addressed using other species.
The PBMCs of NHP such as African Green Monkey, Baboon, Beagle, Cebus, Cynomolgus monkey, Marmoset, Rhesus monkey, Squirrel monkey are available as pooled or individual samples, with either sex as an option. Used for a variety of applications, PBMCs are frequently utilized in drug discovery/development, assay validation/development, and other immunology applications. Creative Biolabs offers isolated PBMCs from NHPs and can provide cytokine release assay (CRA) assay services with the help of our featured NHP PBMCs products. Flow cytometry analysis of the NHP PBMCs will be conducted to demonstrate the expression of cell surface cytokine biomarkers. Further in vitro CRA service andin vitro cytotoxicity analysis service are also available.
If you are interested in our NHP PBMCs model for CRS research, please feel free to contact us to find suitable products and services to support your specific program.
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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