CD23 (Cluster of Differentiation 23), also known as FcεRII, is a "low-affinity" receptor for immunoglobulin E (IgE). It plays an important roll in regulation of IgE levels. CD23 is a C-type lectin, usually found on mature B cells, activatd macrophages,eosiophis, follicular denditic cells and platelets. CD23 is one of the most useful markers for identifying B cell chronic lymphocytic leukemia(CLL). Lymphomas arising from the mantle zone are generally negative for CD23, but most B-cell chronic lymphomocytic leukaemias and low-grade B-cell lymphomas are positive.
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