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Lenti-CD23 CAR (scFv-28εRIγ, Tü1)-VP (VP-CAR-LC236)

The ready-to-use lentiviral particles of Lenti-CD23 CAR (scFv-28εRIγ, Tü1)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (Tü1)-CD28-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • CD23
  • Expression Cassette
  • scFv (Tü1)-CD28-FcεRIγ
  • Clone
  • Tü1
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Chronic lymphocytic leukemia (CLL)

Target

  • Introduction
  • The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Alternative Names
  • FCER2; Fc fragment of IgE, low affinity II, receptor for (CD23); CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2; Chronic lymphocytic leukemia; leukemia; CLL; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; Tü1

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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