DOTA, with a full name of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, is an organic compound. Its not a cancer cell surface molecule biomarker, but usually used as a complexing agent, especially for lanthanide ions. Its complexes have medical applications as contrast agents and cancer treatments.DOTA can be conjugated to monoclonal antibodies by attachment of one of the four carboxyl groups as an amide. The remaining three carboxylate anions are available for binding to the yttrium ion. The modified antibody accumulates in the tumour cells, concentrating the effects of the radioactivity of 90Y.

Associated Disease
  • Various cancer cells stained with DOTA-labeled antibodies
  • Others

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