The vector of anti-DOTA chimeric antigen receptor (CAR) is universal CAR constructed for the engineering of T cell to target DOTA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-DOTA antibody linked to CD137 (4-1BB) and CD3ζ signaling domains. And the vector product was designed for the treatment of various cancers of which the cancer cells are stained with specific DOTA-labeled Mab.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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