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HLA-A2

Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).

Associated Disease
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-MZ109 Anti-HLA-A2 (BB7.2) h(CD3ζ) CAR, pCDCAR1 Human BB7.2 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ110 Anti-HLA-A2 (BB7.2) h(CD28-CD3ζ) CAR, pCDCAR1 Human BB7.2 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ111 Anti-HLA-A2 (BB7.2) h(41BB-CD3ζ) CAR, pCDCAR1 Human BB7.2 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-M0176-YC Anti-HLA-A2 (BB7.2) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human BB7.2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0587-YC Anti-HLA-A2 (BB7.2) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human BB7.2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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