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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-0622-ZP3303 | Anti-HLA-A2 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3475 | Anti-HLA-A2 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0922-ZP971 | Anti-HLA-A2 (SN607D8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | SN607D8 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-ZP1118 | Anti-HLA-A2 (GCT615) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | GCT615 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-ZP1281 | Anti-HLA-A2 (SN607D8) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | SN607D8 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-YF512 | Anti-HLA-A2 KIR CAR (scFv-KIR2DS2-DAP12, XW-512), pCDCAR1 | Human | XW-512 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF513 | Anti-HLA-A2 KIR CAR (scFv-KIR2DS2-DAP12, XW-513), pCDCAR1 | Human | XW-513 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1432 | Anti-HLA-A2 TCR-ABR (scFv-TCRα, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF1433 | Anti-HLA-A2 TCR-ABR (scFv-TCRα, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2352 | Anti-HLA-A2 TCR-ABR (scFv-TCRβ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF2353 | Anti-HLA-A2 TCR-ABR (scFv-TCRβ, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3272 | Anti-HLA-A2 TCR-ABR (scFv-CD3γ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF3273 | Anti-HLA-A2 TCR-ABR (scFv-CD3γ, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4192 | Anti-HLA-A2 TCR-ABR (scFv-CD3δ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF4193 | Anti-HLA-A2 TCR-ABR (scFv-CD3δ, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5112 | Anti-HLA-A2 TCR-ABR (scFv-CD3ε, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF5113 | Anti-HLA-A2 TCR-ABR (scFv-CD3ε, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF7872 | Anti-HLA-A2 (XW-512) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-512 | Mouse | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-0123-ZP624 | Anti-HLA-A2 (SN607D8) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | SN607D8 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0123-ZP855 | Anti-HLA-A2 (GCT615) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | GCT615 | Mouse | scFv-CD3ε | Lentiviral vector | T cell |
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