Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).

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