HLA-A2

Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ109 T cell First BB7.2 ~8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-MZ110 T cell Second BB7.2 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ111 T cell Second BB7.2 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC808 BB7.2 Lentivirus First scFv (BB7.2)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC809 BB7.2 Lentivirus Second scFv (BB7.2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC810 BB7.2 Lentivirus Second scFv (BB7.2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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