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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-MZ109 | Anti-HLA-A2 (BB7.2) h(CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-MZ110 | Anti-HLA-A2 (BB7.2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-MZ111 | Anti-HLA-A2 (BB7.2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-M0176-YC | Anti-HLA-A2 (BB7.2) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-M0587-YC | Anti-HLA-A2 (BB7.2) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0622-ZP3303 | Anti-HLA-A2 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3475 | Anti-HLA-A2 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF512 | Anti-Human HLA-A2 (XW-512) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF513 | Anti-Human HLA-A2 (XW-513) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1432 | Anti-Human HLA-A2 (XW-512) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1433 | Anti-Human HLA-A2 (XW-513) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2352 | Anti-Human HLA-A2 (XW-512) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2353 | Anti-Human HLA-A2 (XW-513) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0922-ZP971 | Anti-HLA-A2 (SN607D8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | SN607D8 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-ZP1118 | Anti-HLA-A2 (GCT615) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | GCT615 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-YF6952 | Anti-HLA-A2 (XW-512) h(41BB-CD3ζ) CAR, pAAV | Human | XW-512 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF6953 | Anti-HLA-A2 (XW-513) h(41BB-CD3ζ) CAR, pAAV | Human | XW-513 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-0323-ZP624 | Anti-HLA-A2 (SN607D8 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | SN607D8 | Mouse | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-ZP855 | Anti-HLA-A2 (GCT615 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | GCT615 | Mouse | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0923-LX48 | Anti-hHLA-A2 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector | Human | X9X-17 | scFv-CD28-41BB-CD3ζ-duplex CTLA4 | Lentiviral vector | T cell | CAR-T |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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