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LCK

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Gene of LCK is a member of the Src family of protein tyrosine kinases (PTKs). LCK is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. Diseases associated with LCK include Immunodeficiency 22 and Cd45 Deficiency. Among its related pathways are T cell receptor signaling pathway and NF-kappa B signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is HCK.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YJ043 Anti-LCK (1526CT823.75.16) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1526CT823.75.16 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ044 Anti-LCK (33D196) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse 33D196 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ045 Anti-LCK (3A5) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat 3A5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ046 Anti-LCK (3E5-C8-B9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3E5-C8-B9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ047 Anti-LCK (845CT3-5-2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 845CT3-5-2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ048 Anti-LCK (8E5F9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 8E5F9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ049 Anti-LCK (LCK-01) h(41BB-CD3ζ) CAR, pCDCAR1 Human LCK-01 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ050 Anti-LCK (7H125) h(41BB-CD3ζ) CAR, pCDCAR1 Human 7H125 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ543 Anti-LCK (1526CT823.75.16) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1526CT823.75.16 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ544 Anti-LCK (33D196) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse 33D196 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ545 Anti-LCK (3A5) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat 3A5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ546 Anti-LCK (3E5-C8-B9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3E5-C8-B9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ547 Anti-LCK (845CT3-5-2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 845CT3-5-2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ548 Anti-LCK (8E5F9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 8E5F9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ549 Anti-LCK (LCK-01) h(CD28-CD3ζ) CAR, pCDCAR1 Human LCK-01 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ550 Anti-LCK (7H125) h(CD28-CD3ζ) CAR, pCDCAR1 Human 7H125 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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