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TERT

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Associated Disease
  • TCR Vector Products
  • TCR Viral Particles
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  • Antibody Host:
  • Epitope:
  • HLA:
CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
TCR-L232 Mouse anti-TERT T cell receptor, pCDTCR1 Human Mouse RLVDDFLLV HLA-A02 Lentiviral   Inquiry
  Datasheet
TCR-C246Z Human anti-TERT T cell receptor (ILA1β2), pCDTCR1 Human ILA1β2 Human ILAKFLHWL HLA-A2 Lentiviral   Inquiry
  Datasheet

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