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A uniCAR [anti-CD16 (FCGR3A) V158 variant-CD8ɑ/41BB/ CD3ζ], with a mAb-based CAR Adaptor [Anti-CD20 (Rituximab)], a Switchable CAR System (CAR-ZP8489)

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative Biolabs has developed a switchable CAR (sCAR) T cell platform that allows dose-titratable control over CAR T cell activity by using adaptor-based switches. Our switchable CAR product aims to further evolve CAR-T cell therapy based on combinations of so-called universal or modular CAR-(uniCAR/modCAR-) T cells, and their respective adaptor molecules (CAR-adaptors), which mediate the crosslinking between target and effector cells. Thus, the universal or modCARs describe chimeric receptors that do not directly recognize the target antigen, but instead make contact to adaptor molecules (CAR-adaptors), that in turn bind to the target antigen. Contrary to conventional CAR-T cells, where the immunological synapse is established by direct interaction of CAR and membrane-bound target, modCAR-T cells provide a highly flexible and customizable development of the CAR-T cell concept and offer an additional possibility to control T cell activity.

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UniCAR

  • scFv Target
  • CD16
  • CAR Construction
  • anti-CD16 (FCGR3A) V158 variant-CD8ɑ/41BB/ CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Mature B cell neoplasms

CAR Adaptor

  • Common Name
  • MS4A1
  • Adaptor Type
  • mAb-based
  • Antibody Clone
  • Rituximab
  • CAR Adaptor Tag
  • IgG-biotinylated

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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