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Anti-EBV Determinant Variant T cell receptor ((LC13)-1), pCDTCR1 (TCR-YC0341)

The recognition of HLA-B8-FLRGRAYGL by two archetypal TCRs was compared. One was a publicly selected TCR, LC13, that is alloreactive with HLA-B44; the other, CF34, lacks HLA-B44 reactivity because it arises when HLA-B44 is coinherited in trans with HLA-B8. Whereas the alloreactive LC13 TCR docked at the C terminus of HLA-B8-FLRGRAYGL, the CF34 TCR docked at the N terminus of HLA-B8-FLRGRAYGL, which coincided with a polymorphic region between HLA-B8 and HLA-B44. The markedly contrasting footprints of the LC13 and CF34 TCRs provided a portrait of how self-tolerance shapes the specificity of TCRs selected into the immune repertoire.

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Details

  • Target
  • EBV Determinant Variant
  • Target Species
  • EBV
  • Epitope
  • FLRGRAFGL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-B*08:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • LC13
  • Host Species
  • Human

Target

  • Introduction
  • It has been explored the in vivo memory cytotoxic T lymphocyte (CTL) response to an immunodominant HLA-B8-restricted epitope, FLRGRAYGL, from the latent EBV antigen, EBNA 3A. Remarkably, the immune response to HLA-B8-FLRGRAYGL is characterized by type III-biased TCR usage (the reproducible selection of clonal TCR sequences) identifiable in unrelated HLA-B8+ individuals.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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