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Anti-EXOC8 Q656P T cell receptor (MEL218), pCDTCR1 (TCR-YC0384)

The vector of anti-EXOC8 Q656P T cell receptor (TCR) is constructed for the engineering of T cell to target EXOC8 Q656P (IILVAVPHV) restricted by HLA-A*02:01. The T cells are genetically modified through transduction with a lentiviral vector expressing EXOC8 Q656P-specific T cell receptor.

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Details

  • Target
  • EXOC8 Q656P
  • Epitope
  • IILVAVPHV
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • MEL218
  • Host Species
  • Human

Target

  • Introduction
  • TMEM48 F169L, SEC24A P469L, and EXOC8 Q656P represent dominant antigens as T cell immunity was detected prior to vaccination (naturally occurring) and these neoantigens are processed and presented from endogenously expressed protein. TKT R438W, CDKN2A E153K, AKAP13 Q285K and PABPC1 R520Q are characterized as subdominant antigens as T cell immunity required peptide vaccination and these neoantigens are processed and presented from endogenously expressed protein.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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All services and products are only for lab research use, not for any clinical diagnosis or treatment.

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