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Anti-PLP1 T cell receptor (Clone 2), pCDTCR1 (TCR-YF097)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-PLP1 T cell receptor (TCR) is constructed for the engineering of T cell to target PLP1. The T cells are genetically modified through transduction with a lentiviral vector expressing PLP1-specific T cell receptor. And the vector product was designed for the treatment of Autoimmune Disease.

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Details

  • Target
  • PLP1
  • Target Species
  • Mouse
  • Epitope
  • HSLGKWLGHPDKF
  • Format
  • Non-modified
  • Allele
  • H2-s class II
  • Targeting Diseases
  • Autoimmune Disease
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Clone 2
  • Host Species
  • Mouse

Target

  • Introduction
  • This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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