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Anti-Mesothelin T cell receptor, pCDTCR1 (TCR-ZP055)

The vector of anti-Mesothelin T cell receptor (TCR) is constructed for the engineering of T cell to target Human Mesothelin. The T cells are genetically modified through transduction with a lentiviral vector expressing Mesothelin-specific T cell receptor. And the vector product was designed for the treatment of Pancreatic, ovarian, and lung adenocarcinomas.

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Details

  • Target
  • Mesothelin
  • Target Species
  • Human
  • Epitope
  • SLLFLLFSL
  • Format
  • Non-Modified TCR
  • HLA
  • HLA-A*201
  • Targeting Diseases
  • Pancreatic, ovarian, and lung adenocarcinomas
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Antibody Clone
  • CBL-Z013
  • Antibody Host
  • Mouse

Target

  • Official Symbol
  • MSLN
  • Gene ID
  • 10232
  • Introduction
  • This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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