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Anti-NSDHL T cell receptor (K11), pCDTCR1 (TCR-YC0767)

The vector of anti-NSDHL T cell receptor (TCR) is constructed for the engineering of T cell to target Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (ILTGLNYEA) restricted by HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing NSDHL-specific T cell receptor.

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Details

  • Target
  • NSDHL
  • Target Species
  • Human
  • Epitope
  • ILTGLNYEA
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A2
  • Targeting Diseases
  • CHILD syndrome
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • K11
  • Host Species
  • Human

Target

  • Introduction
  • The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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