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Anti-Coagulation Factor VIII T cell receptor, pCDTCR1 (TCR-ZP177)

The vector of anti-Coagulation Factor VIII T cell receptor (TCR) is constructed for the engineering of T cell to target Human. The T cells are genetically modified through transduction with a lentiviral vector expressing Coagulation Factor VIII-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.

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Details

  • Target
  • Coagulation Factor VIII
  • Target Species
  • Human
  • Epitope
  • SYFTNMFATWSPSKARLHLQ
  • Format
  • Non-modified
  • Allele
  • HLA-DR1
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Melanoma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 32A-21

Target

  • Introduction
  • This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X linked coagulation disorder.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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