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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The 506β mice infected with Vac:IAb–3K expanded a large population of IFNγ-producing CD4 T cells that recognized the 3K variant ligands, P-1L and P-1K. In contrast, Vac:3K–GFP expanded CD4 T cells with these cross-reactivities very poorly. An increased precursor frequency of CD4 T cells in 506β mice for 3K and the 3K APLs may allow these lower potency, P-1L and P-1K cross-reactive CD4 T cells to be expanded following Vac:IAb–3K infections, whereas in a completely polyclonal population these cells would fail to be activated because of some aspect of T-cell competition.
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