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Anti-LMP2 (CLGGLLWT) TCR, pSFG (TCR-L056)

The vector of anti-LMP2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV LMP2. The T cells are genetically modified through transduction with a retroviral vector expressing LMP2-specific T cell receptor. And the vector product was designed for the treatment of Hodgkin's Disease and Nasopharyngeal Carcinoma.

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Details

  • Target
  • LMP2
  • Target Species
  • EBV
  • Epitope
  • CLGGLLWT
  • Format
  • Non-modified TCR
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Hodgkin's Disease and Nasopharyngeal Carcinoma
  • Vector Name
  • pSFG
  • Vector Length
  • 8200bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Human

Target

  • Official Symbol
  • LMP2
  • Introduction
  • Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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