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Anti-PLP T cell receptor ((5B6)-2), pCDTCR1 (TCR-YC0993)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

PLP1 peptide (HSLGKWLGHPDKF) encompasses an encephalitogenic sequence corresponding to aa 139-151 of PLP, PLP1-LR (HSLGKLLGRPDKF) is an altered peptide form of PLP1 in which the TCR contact residues Trp144 and His147 were replaced with Leu and Arg, respectively. PLP1-Y (HSLGKYLGHPDKF) is an altered peptide form of PLP1 in which the TCR contact residue Trp144 was replaced with Tyr 144. PLP1, PLP-LR, and PLP-Y peptides bind equally well to I-As class II molecules.

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Details

  • Target
  • PLP
  • Target Species
  • Mouse
  • Epitope
  • HSLGKYLGHPDKF
  • Format
  • Non-Modified TCR
  • Allele
  • H2 class II
  • Targeting Diseases
  • Autoimmune encephalomyelitis (EAE)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 5B6
  • Host Species
  • Mouse

Target

  • Introduction
  • The SJL/J mouse expresses only the DM20 form of proteolipid protein (PLP) during fetal and neonatal life. DM20 is a splice variant of PLP missing the immunodominant PLP1 sequence corresponding to amino acid residues 139-151 of PLP. Due to this genetic trait of the SJL/J mouse, thymic negative selection against PLP1 is defective during the fetal/neonatal period and the mice accumulate a high frequency of PLP1-reactive T cells in the normal autoimmune repertoire. Likewise selection of Tregs on PLP1 should not be operative during such a period.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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