Sarcoma Specific CAR Construction Service

Are you currently facing long development cycles, difficulty in identifying specific targets, and complex challenges inherent in developing effective immunotherapies for solid tumors like sarcoma? Our sarcoma-specific CAR construction service helps you accelerate drug discovery, obtain high-quality CAR constructs, and develop highly specific T-cell therapies through advanced CAR engineering and rigorous validation.

Introduction

Sarcoma is a cancer that usually occurs in connective tissues like bone or soft tissues. It can also develop in any other parts of the body. This kind of disease can be divided into two main types: Bone sarcomas and soft tissue sarcomas. The traditional approaches for treating sarcoma include surgery, radiation therapy, and chemotherapy, which always have severe side effects and less effectiveness. However, increasing evidences demonstrate that immunotherapy utilizing the immune system can be developed as a novel, powerful tool to attack cancer.

Sarcoma-Specific CAR Construction Service at Creative Biolabs

At Creative Biolabs, our sarcoma-specific CAR construction service is meticulously designed to provide comprehensive solutions for developing potent and precise CAR T-cell therapies against these aggressive cancers. We address the unique challenges of solid tumors, including antigen heterogeneity, the immunosuppressive tumor microenvironment, and T-cell trafficking limitations, by offering tailored CAR designs and robust validation.

With many years of experience, experts from Creative Biolabs have constructed a series of CAR products targeting antigens from different types of sarcoma:

• Bone sarcomas (osteosarcoma, Ewing's sarcoma, and chondrosarcoma);
• Soft tissue sarcomas (rhabdomyosarcoma and Leiomyosarcomas, Fibroblastic sarcomas, Liposarcomas, Synovial sarcomas, Vascular sarcomas, MPNST, GIST, etc.)

Service Process

Key Advantages

• Advanced Target Antigen Identification: Leverage our expertise in identifying novel sarcoma-associated antigens and tumor-specific antigens. Our rigorous validation processes ensure high specificity, minimizing off-target effects on healthy tissues.
• High-Quality Gene Synthesis & Vector Production: We ensure optimal CAR expression through codon-optimized gene synthesis and the construction of high-titer viral or non-viral vectors, crucial for efficient T-cell transduction.
• Robust In Vitro and In Vivo Functional Validation: Our comprehensive preclinical validation services include detailed in vitro assays and optional in vivo studies using xenograft models.

Typical data

Summary: This study focuses on paediatric sarcomas with poor advanced-stage survival and limited therapeutic progress. It developed a targeted CAR-NK cell therapy, using mRNA transfection to engineer NK cells. Results showed successful CAR expression, enhanced in vitro cytotoxicity against sarcoma cell lines vs unmodified NK cells, and promising in vivo anti-tumour activity in mouse models. The target antigen, overexpressed in these sarcomas, is a viable target.

Fig.1 The anti-cancer efficacy of CAR-NK cells.¹

FAQs

Why Choose Us?

Creative Biolabs is dedicated to accelerating the development of life-changing immunotherapies for sarcoma. Our sarcoma-specific CAR construction service, backed by two decades of expertise and cutting-edge platforms, offers a precise, comprehensive, and efficient pathway from target identification to validated CAR constructs. We are committed to partnering with you to overcome the unique challenges of solid tumors and bring effective treatments to patients in need.

Customer Reviews

"The ability to explore novel sarcoma-associated antigens ligands through Creative Biolabs' service was a game-changer. Their rigorous validation of these targets and the subsequent construction of highly functional CARs provided us with a unique therapeutic avenue we hadn't previously considered. Their insights into the challenges of solid tumor microenvironments made their solutions stand out." - Dr. M. Cha***, Director of Oncology Research

"Using Creative Biolabs' sarcoma-specific CAR construction service in our research has significantly improved the specificity of our CAR-T constructs. Their affinity optimization strategies allowed us to target sarcoma cells effectively while minimizing off-target effects on healthy tissues, a crucial advantage compared to our previous attempts with generic CAR designs." - Dr. J. Smi***, Lead Researcher

How to Contact Us

Ready to advance your sarcoma CAR T-cell therapy project? Our expert team is here to provide detailed information, discuss your specific project requirements, and offer tailored solutions.

Products against Sarcoma-specific antigens

Please note: New products are updated every month. If you do not find the information that meet your needs, please feel free to contact us. We are always here to assist you.

Reference

1. Lam, Pui Yeng et al. "Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR." Clinical and translational medicine vol. 15,1 (2025): e70140. https://doi.org/10.1002/ctm2.70140. Distributed under Open Access License CC BY 4.0, without modification.