Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Overview
Nephroblastoma, also called Wilms tumor or Wilms’ tumor, was first described by German surgeon Max Wilms in 1899. Most nephroblastomas affect only one kidney but in 5-10% of cases, both kidneys are involved meantime or one after the other. It is the most common childhood kidney cancer but rarely found in adults. Approximately, 90% of kidney cancers and 6-7% of all childhood cancers in children are nephroblastoma. In the US, approximately 450-500 cases are diagnosed each year. Higher prevalence of nephroblastoma has been reported in blacks relative to whites and Asians. And nephroblastoma is more common in females than males. It is possibly caused by alterations of genes which are responsible for the development of genitourinary, such as WT1 gene.
Signs, symptoms and treatments
In the early stage, there are no apparent signs and symptoms of nephroblastoma, therefore it is hard to find it early. Once noticed, the tumor may be many times larger than the kidney where it started. Typical signs and symptoms of nephroblastoma include swelling or hard mass in the abdomen, loss of appetite, fever, nausea, constipation, blood in the urine and high blood pressure. Treatment is mainly based on the type and stage of nephroblastoma. Surgery is firstly used in most cases, and followed with chemotherapy and possibly radiation therapy. At present, the survival rates of children with nephroblastoma are about 80-90% with combination therapy.
Loading...
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTER
NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTION
NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGY
NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION
