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pCDCAR1 CD20 h(FcγRIII) (CAR-MZ055)

The vector of anti-CD20 chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human CD20. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD20 antibody linked to FcγRIII signaling domains. And the vector product was designed for the treatment of Chronic lymphocytic leukemia (CLL).

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Details

  • Target
  • CD20
  • Targeting Cell Type
  • NK cell
  • Targeting Diseases
  • Chronic lymphocytic leukemia (CLL)
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcγRIII
  • Discription of Signaling Cassetes
  • FcγR
    Fc-gamma receptors (FcγR) are Fc receptors (abbreviated FcR) for antibody IgG. All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (marked) microbes. This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure.

Target

  • Clone
  • Ofatumumab
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • Membrane Spanning 4-Domains A1
  • Synonyms
  • Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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