Costimulatory Protein expressed Artificial T Cell Stimulator Development Service

The Significance of Costimulatory Protein expressed Artificial T Cell Stimulator Development

Co-stimulatory molecules are essential signals that activate T cells. Artificial T cell Stimulators have proven crucial in boosting the effectiveness and longevity of T cell therapies by offering continuous stimulation and promoting T cell expansion. Research indicates that displaying co-stimulatory molecules on artificial T cell stimulators can enhance T cell activation and improve the capability of artificial T cell stimulators to guide T cell responses toward desired targets. This strategy shows significant promise for advancing immunotherapies against cancer, infectious diseases, and autoimmune disorders by creating strong and specific T cell responses.

Fig.1 Co-stimulatory signaling expressed artificial T cell stimulators stimulate T cell activation and differentiation.^1,3

Costimulatory Protein expressed Artificial T Cell Stimulator Development Service at Creative Biolabs

Creative Biolabs delivers a costimulatory protein-expressed artificial T cell stimulator development service for clients worldwide, aimed at advancing and enhancing T cell therapies. Our service employs specialized expression vectors carrying co-stimulatory molecules to transform/transduce non-antigen presenting cells (non-APCs), allowing them to stably express co-stimulatory molecules and enhance the effector function of T cell activation. By engineering non-APCs to express these critical costimulatory molecules, we strive to replicate the interactions that naturally occur between APCs and T cells within the immune system, without reliance on exogenous cytokines or feeder cells. Leveraging our profound expertise in cell biology, molecular biology, and immunology, we collaborate closely with our clients to develop tailored solutions that align with their research and development objectives.

In addition to the artificial T cell stimulator mentioned above, we can customize and manufacture various types of artificial T cell stimulators based on your experimental design, including but not limited to:

• MHC Class II Protein expressed Artificial T Cell Stimulator
• Metal Nanoparticle coupled Artificial T Cell Stimulator
• Polymer-based Beads coupled Artificial T Cell Stimulator
• Cell-based Artificial T Cell Stimulator

Published Data

The research focuses on the development of an innovative and universally applicable immunotherapy based on γδ-T lymphocytes. Researchers utilized artificial T cell stimulators to express various co-stimulatory molecules, aiming to assess the polyclonality and activation characteristics of γδ-T cells, as well as their successful expansion. The findings revealed that incorporating co-stimulatory molecules on artificial T cell stimulators significantly promoted the expansion of γδ-T cells.

Fig.2 Artificial T cell stimulators design and the expansion of isolated γδ-T cells stimulated with artificial T cell stimulators.^2,4

Creative Biolabs possesses a wealth of experience and a robust theoretical foundation in T cell biology, cultivated over many years of dedicated research. This deep understanding, coupled with extensive practical expertise, empowers us to effectively customize and develop high-quality artificial T cell stimulators, thereby precisely meeting your specific research or therapeutic requirements. To explore the full range of possibilities and discuss your unique needs, please don't hesitate to reach out to us for a detailed consultation.

References

1. Li, Jing, Weilin Zhou, and Wei Wang. "Artificial antigen-presenting cells: the booster for the obtaining of functional adoptive cells." Cellular and Molecular Life Sciences 81.1 (2024): 378.
2. Polito, Vinicia A., et al. "Universal ready-to-use immunotherapeutic approach for the treatment of cancer: expanded and activated polyclonal γδ memory T cells." Frontiers in Immunology 10 (2019): 2717.
3. Distributed under Open Access License CC BY 4.0. The original image was modified by extracting and using part B, and the title was changed to "Co-stimulatory signaling expressed aAPCs stimulate T cell activation and differentiation".
4. Distributed under Open Access License CC BY 4.0. The original image was modified by extracting and regrouping parts A and D, and the title was changed to "aAPCs design and the expansion of isolated γδ-T cells stimulated with aAPCs".