The immunoglobulin light chain is the small polypeptide subunit of an antibody. There are two types of light chain in humans,kappa (κ) chain and lambda (λ) chain. Using immunohistochemistry, it is possible to determine the relative abundance of B-cells expressing kappa and lambda light chains. If one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma. It can be detected with varying frequencies in other B-cell malignancies such as chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma(NHL).
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