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pCDCAR1 Kappa light chain h(BBζ) (CAR-LC217)

The vector of anti-Kappa light chain chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human Kappa light chain. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-Kappa light chain antibody linked to CD3ζ and 4-1BB (CD137) signaling domains. And the vector product was designed for the treatment of non-Hodgkin's lymphoma.

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Details

  • Target
  • Kappa light chain
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Non-Hodgkin lymphomas
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Ig kappa light chain
  • Synonyms
  • Kappa light chain; Ig kappa light chain; IGK
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