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Lenti-Kappa light chain CAR (scFv-BBζ)-VP (VP-CAR-LC692)

The ready-to-use lentiviral particles of Lenti-Kappa light chain CAR (scFv-BBζ)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • Kappa light chain
  • Expression Cassette
  • scFv-41BB-CD3ζ
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Non-Hodgkin lymphomas

Target

  • Introduction
  • Immunoglobulin kappa locus, also known as IGK, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).
    In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.
  • Alternative Names
  • IGK; immunoglobulin kappa; Km; HCAK1; IGKCD; IGKV; IGKV1; IGKV2; IGKV3; IGKV1@; IGKV2@; IGKV3@; B cell-chronic lymphocytic leukemia; B-CLL; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; IR506/IS506

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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