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MBP

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The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Associated Disease
  • Multiple sclerosis (MS)
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-M0217-YC Anti-MBP (2H9) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 2H9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0218-YC Anti-MBP (Clone 2) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Cattle Clone 2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0628-YC Anti-MBP (2H9) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 2H9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0629-YC Anti-MBP (Clone 2) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Cattle Clone 2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6919 Anti-MBP (CBX-001) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBX-001 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6920 Anti-MBP (CBX-051) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Sheep, Rabbit, Goat, Human CBX-051 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6921 Anti-MBP (BA0318) h(CD28-CD3ζ) CAR, pCDCAR1 Human BA0318 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6922 Anti-MBP (BA0080) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human BA0080 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6923 Anti-MBP (CBX-047) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBX-047 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7399 Anti-MBP (CBX-001) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBX-001 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7400 Anti-MBP (CBX-051) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Sheep, Rabbit, Goat, Human CBX-051 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7401 Anti-MBP (BA0318) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human BA0318 Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7402 Anti-MBP (BA0080) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human BA0080 Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7403 Anti-MBP (CBX-047) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBX-047 Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7040 Anti-MBP (CBFYM-1840) h(41BB-CD3ζ) CAR, pCDCAR1 Rat CBFYM-1840 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7838 Anti-MBP (CBFYM-1840) h(CD28-CD3ζ) CAR, pCDCAR1 Rat CBFYM-1840 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-MV-01LX239 Anti-MBP (F11) h(CD28-CD3ζ) CAR, pMMLV Human F11 Human scFv-CD28-CD3ζ Recombinant Moloney murine leukemia virus (MMLV) retroviral vector T cell   Add to Cart   Datasheet
CAR-MV-01LX240 Anti-MBP (NT12a) h(CD28-CD3ζ) CAR, pMMLV Human NT12a Human scFv-CD28-CD3ζ Recombinant Moloney murine leukemia virus (MMLV) retroviral vector T cell   Add to Cart   Datasheet
CAR-MV-01LX241 Anti-MBP (NT18) h(CD28-CD3ζ) CAR, pMMLV Human NT18 Human scFv-CD28-CD3ζ Recombinant Moloney murine leukemia virus (MMLV) retroviral vector T cell   Add to Cart   Datasheet
CAR-MV-01LX242 Anti-MBP (NT5) h(CD28-CD3ζ) CAR, pMMLV Human NT5 Human scFv-CD28-CD3ζ Recombinant Moloney murine leukemia virus (MMLV) retroviral vector T cell   Add to Cart   Datasheet
XS-0823-LX77 Anti-hMBP (A10) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector Human A10 Adenoviral vectors   Add to Cart   Datasheet
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