MBP

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Associated Disease
  • Multiple sclerosis (MS)

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C146Z MBP Human Hy.2E11 Murinized ~8kb Lentiviral ENPVVHFFKNIVTPR Murinized HLA-DRB1*1501 Inquiry
TCR-C147Z MBP Human 172.10 Mouse ~8kb Lentiviral SRGGASQYRPSQ Non-modified I-Au Inquiry
TCR-C148Z MBP Human Ob.1A12 Human ~8kb Lentiviral ENPVVHFFKNIVTPR Non-modified HLA-DR2 Inquiry
TCR-C149Z MBP Human 3A6 Human ~8kb Lentiviral VHFFKNIVTPRTP Non-modified HLA-DR2a Inquiry
TCR-C150Z MBP Human 1.D9.B2 Mouse ~8kb Lentiviral GGRASDYKSAH Single-chain I-Au Inquiry
TCR-C151Z MBP Human 1.D9.B2 Mouse ~8kb Lentiviral KGFKGAYDAQG Single-chain I-Au Inquiry
TCR-C152Z MBP Human OB Human ~8kb Lentiviral aa 84-102 Non-modified HLA-DR2b Inquiry
TCR-C153Z MBP Human MS2-3C8 Human ~8kb Lentiviral aa 111-129 Non-modified HLA-DR4 Inquiry
TCR-C154Z MBP Human Hy.1B11 Human ~8kb Lentiviral ENPVVHFFKNIVTPR Non-modified HLA-DQ1 Inquiry
TCR-C155Z MBP Human Hy.1F9 Human ~8kb Lentiviral aa 84-102 Non-modified HLA-DR2 Inquiry
TCR-C156Z MBP Human Murinized ~8kb Lentiviral KIFKLGGRDSRSGSPMARR Murinized HLA-DR13 Inquiry
TCR-L069Z MBP Human Human 8kb Lentiviral MBP[89-101] Non-modified HLA-A2 Inquiry
TCR-L070 MBP Human Human 6714-6688bp retroviral vector MBP[89-101] Non-modified TCR HLA-A2 Inquiry
TCR-L269 MBP Human Hy.2H9 Human ~8kb Lentiviral aa 85-99 Non-modified HLA-DR2 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C259 Human Hy.2E11 Murinized Lentivirus ENPVVHFFKNIVTPR Murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C260 Human 172.10 Mouse Lentivirus SRGGASQYRPSQ Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C261 Human Ob.1A12 Human Lentivirus ENPVVHFFKNIVTPR Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C262 Human 3A6 Human Lentivirus VHFFKNIVTPRTP Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C263 Human 1.D9.B2 Mouse Lentivirus GGRASDYKSAH Single-chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C264 Human 1.D9.B2 Mouse Lentivirus KGFKGAYDAQG Single-chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C265 Human OB Human Lentivirus aa 84-102 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C266 Human MS2-3C8 Human Lentivirus aa 111-129 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C267 Human Hy.1B11 Human Lentivirus ENPVVHFFKNIVTPR Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C268 Human Hy.1F9 Human Lentivirus aa 84-102 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C269 Human Murinized Lentivirus KIFKLGGRDSRSGSPMARR Murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C270 Human Hy.2H9 Human Lentivirus aa 85-99 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C271 Human Human Lentivirus DENPWHFFKNIVTPRTPP Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C272 Human Human Lentivirus aa 89-101 Non-modified TCR > 10⁷ IFU/ml Inquiry
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