Anti-MBP TCR Products - Creative Biolabs

MBP

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Associated Disease

Multiple sclerosis (MS)

Vector Products
Viral Particles

TCR Vector Products Product list:

Catalog	Target	Target Species	Antibody Clone	scFv-Host Animal	Vector length	Vector Type	Epitope	Format	HLA	Data sheet	Price
TCR-C146Z	MBP	Human	Hy.2E11	Murinized	~8kb	Lentiviral	ENPVVHFFKNIVTPR	Murinized	HLA-DRB1*1501		Inquiry
TCR-C147Z	MBP	Human	172.10	Mouse	~8kb	Lentiviral	SRGGASQYRPSQ	Non-modified	I-Au		Inquiry
TCR-C148Z	MBP	Human	Ob.1A12	Human	~8kb	Lentiviral	ENPVVHFFKNIVTPR	Non-modified	HLA-DR2		Inquiry
TCR-C149Z	MBP	Human	3A6	Human	~8kb	Lentiviral	VHFFKNIVTPRTP	Non-modified	HLA-DR2a		Inquiry
TCR-C150Z	MBP	Human	1.D9.B2	Mouse	~8kb	Lentiviral	GGRASDYKSAH	Single-chain	I-Au		Inquiry
TCR-C151Z	MBP	Human	1.D9.B2	Mouse	~8kb	Lentiviral	KGFKGAYDAQG	Single-chain	I-Au		Inquiry
TCR-C152Z	MBP	Human	OB	Human	~8kb	Lentiviral	aa 84-102	Non-modified	HLA-DR2b		Inquiry
TCR-C153Z	MBP	Human	MS2-3C8	Human	~8kb	Lentiviral	aa 111-129	Non-modified	HLA-DR4		Inquiry
TCR-C154Z	MBP	Human	Hy.1B11	Human	~8kb	Lentiviral	ENPVVHFFKNIVTPR	Non-modified	HLA-DQ1		Inquiry
TCR-C155Z	MBP	Human	Hy.1F9	Human	~8kb	Lentiviral	aa 84-102	Non-modified	HLA-DR2		Inquiry
TCR-C156Z	MBP	Human		Murinized	~8kb	Lentiviral	KIFKLGGRDSRSGSPMARR	Murinized	HLA-DR13		Inquiry
TCR-L069Z	MBP	Human		Human	8kb	Lentiviral	MBP[89-101]	Non-modified	HLA-A2		Inquiry
TCR-L070	MBP	Human		Human	6714-6688bp	retroviral vector	MBP[89-101]	Non-modiﬁed TCR	HLA-A2		Inquiry
TCR-L269	MBP	Human	Hy.2H9	Human	~8kb	Lentiviral	aa 85-99	Non-modified	HLA-DR2		Inquiry

TCR Viral Particles Product list:

Catalog	Target Species	Antibody Clone	scFv-Host Animal	Packaging System	Epitope	Format	Titer	Data sheet	Price
VP-TCR-C259	Human	Hy.2E11	Murinized	Lentivirus	ENPVVHFFKNIVTPR	Murinized TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C260	Human	172.10	Mouse	Lentivirus	SRGGASQYRPSQ	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C261	Human	Ob.1A12	Human	Lentivirus	ENPVVHFFKNIVTPR	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C262	Human	3A6	Human	Lentivirus	VHFFKNIVTPRTP	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C263	Human	1.D9.B2	Mouse	Lentivirus	GGRASDYKSAH	Single-chain TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C264	Human	1.D9.B2	Mouse	Lentivirus	KGFKGAYDAQG	Single-chain TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C265	Human	OB	Human	Lentivirus	aa 84-102	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C266	Human	MS2-3C8	Human	Lentivirus	aa 111-129	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C267	Human	Hy.1B11	Human	Lentivirus	ENPVVHFFKNIVTPR	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C268	Human	Hy.1F9	Human	Lentivirus	aa 84-102	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C269	Human		Murinized	Lentivirus	KIFKLGGRDSRSGSPMARR	Murinized TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C270	Human	Hy.2H9	Human	Lentivirus	aa 85-99	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C271	Human		Human	Lentivirus	DENPWHFFKNIVTPRTPP	Non-modified TCR	> 10⁷ IFU/ml		Inquiry
VP-TCR-C272	Human		Human	Lentivirus	aa 89-101	Non-modified TCR	> 10⁷ IFU/ml		Inquiry

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