MDM2

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Associated Disease
  • Cancer

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L070Z MDM2 Human Mouse 8kb Lentiviral Non-modified HLA-A2 Inquiry
TCR-L071 MDM2 Human Mouse 3111bp retroviral vector STTVTKER Non-modified TCR HLA-A2 Inquiry
TCR-L345 MDM2 Human TCR 1 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L346 MDM2 Human MDM2 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L347 MDM2 Human 1bd2 Human ~8kb Lentiviral aa 81-88 Non-modified HLA-A2.1 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C279 Human TCR 1 Mouse Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C280 Human MDM2 Mouse Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C281 Human 1bd2 Human Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C282 Human Mouse Lentivirus STTVTKER Non-modified TCR > 10⁷ IFU/ml Inquiry
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