MDM2

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Associated Disease
  • Cancer

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-WFY2112 T cell Second CBFYM-0323 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2113 T cell Second CBFYM-0419 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2114 T cell Second CBFYM-0613 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2115 T cell Second CBFYM-1955 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2116 T cell Second CBFYM-1956 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2117 T cell Second CBFYM-1957 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2118 T cell Second CBFYM-1958 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2119 T cell Second CBFYM-1959 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2120 T cell Second CBFYM-1960 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2121 T cell Second CBFYM-1961 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2122 T cell Second CBFYM-1962 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2123 T cell Second CBFYM-1963 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WFY2124 T cell Second CBFYM-1964 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2125 T cell Second CBFYM-1965 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY5365 T cell Second CBFYM-0323 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5366 T cell Second CBFYM-0419 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5367 T cell Second CBFYM-0613 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5368 T cell Second CBFYM-1955 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5369 T cell Second CBFYM-1956 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5370 T cell Second CBFYM-1957 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5371 T cell Second CBFYM-1958 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5372 T cell Second CBFYM-1959 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5373 T cell Second CBFYM-1960 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5374 T cell Second CBFYM-1961 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5375 T cell Second CBFYM-1962 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5376 T cell Second CBFYM-1963 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WFY5377 T cell Second CBFYM-1964 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5378 T cell Second CBFYM-1965 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L070Z MDM2 Human Mouse 8kb Lentiviral Non-modified HLA-A2 Inquiry
TCR-L071 MDM2 Human Mouse 3111bp retroviral vector STTVTKER Non-modified TCR HLA-A2 Inquiry
TCR-L345 MDM2 Human TCR 1 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L346 MDM2 Human MDM2 Mouse ~8kb Lentiviral aa 81-88 Non-modified H-2Kb Inquiry
TCR-L347 MDM2 Human 1bd2 Human ~8kb Lentiviral aa 81-88 Non-modified HLA-A2.1 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C279 Human TCR 1 Mouse Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C280 Human MDM2 Mouse Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C281 Human 1bd2 Human Lentivirus aa 81-88 Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C282 Human Mouse Lentivirus STTVTKER Non-modified TCR > 10⁷ IFU/ml Inquiry

DMAb Product list:

Catalog Target Target Species DMAb Host DMAb Cross Reactivity DMAb Clone Vector Name Data
sheet
Price
DMAb-2112-FY MDM2 Human Mouse Human, Mouse CBFYM-0323 pVAX1 Inquiry
DMAb-2113-FY MDM2 Human Mouse Mouse, Rat, Human CBFYM-0419 pVAX1 Inquiry
DMAb-2114-FY MDM2 Human Mouse Human CBFYM-0613 pVAX1 Inquiry
DMAb-2115-FY MDM2 Human Mouse Human CBFYM-1955 pVAX1 Inquiry
DMAb-2116-FY MDM2 Human Mouse Human CBFYM-1956 pVAX1 Inquiry
DMAb-2117-FY MDM2 Human Mouse Human CBFYM-1957 pVAX1 Inquiry
DMAb-2118-FY MDM2 Human Mouse Human CBFYM-1958 pVAX1 Inquiry
DMAb-2119-FY MDM2 Human Mouse Human CBFYM-1959 pVAX1 Inquiry
DMAb-2120-FY MDM2 Human Mouse Human CBFYM-1960 pVAX1 Inquiry
DMAb-2121-FY MDM2 Human Mouse Human CBFYM-1961 pVAX1 Inquiry
DMAb-2122-FY MDM2 Human Mouse Human, Mouse CBFYM-1962 pVAX1 Inquiry
DMAb-2123-FY MDM2 Human Rabbit Human, Mouse CBFYM-1963 pVAX1 Inquiry
DMAb-2124-FY MDM2 Human Mouse Human, Mouse, Rat CBFYM-1964 pVAX1 Inquiry
DMAb-2125-FY MDM2 Mouse Mouse Mouse CBFYM-1965 pVAX1 Inquiry
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