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Anti-MDM2 T cell receptor (1bd2), pCDTCR1 (TCR-L347)

The vector of anti-MDM2 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MDM2. The T cells are genetically modified through transduction with a lentiviral vector expressing MDM2-specific T cell receptor.

Details

  • Target
  • MDM2
  • Target Species
  • Human
  • Epitope
  • aa 81-88
  • Format
  • Non-modified
  • HLA
  • HLA-A2.1
  • Targeting Diseases
  • Cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • 1bd2
  • Antibody Host
  • Human

Target

  • Gene Name
  • Mdm2 Proto-Oncogene
  • Official Symbol
  • MDM2
  • Synonyms
  • MDM2 Proto-Oncogene; MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase; Oncoprotein Mdm2; Hdm2; Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse); Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein; Mouse Double Minute 2, Human Homolog Of; P53-Binding Protein; Double Minute 2, Human Homolog Of; P53-Binding Protein; Mdm2, P53 E3 Ubiquitin Protein Ligase Homolog; MDM2 Oncogene, E3 Ubiquitin Protein Ligase
  • Introduction
  • This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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