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Anti-AH10-7 T cell receptor (2C12), pCDTCR1 (TCR-YC0067)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-AH10-7 T cell receptor (TCR) is constructed for the engineering of T cell to target AH10-7 ((2S,3R)-1-O-(6-Hydrocinnamoyl-α-D-galactopyranosyl)-2-(N-hexacosanoylamino)octadecane-1,3-diol) restricted by mouse CD1d. The T cells are genetically modified through transduction with a lentiviral vector expressing AH10-7-specific T cell receptor.

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Details

  • Target
  • AH10-7
  • Epitope
  • (2S,3R)-1-O-(6-Hydrocinnamoyl-α-D-galactopyranosyl)-2-(N-hexacosanoylamino)octadecane-1,3-diol
  • Format
  • Non-Modified TCR
  • Allele
  • mouse CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 2C12
  • Host Species
  • Mouse

Target

  • Introduction
  • AH10-7 incorporates a C6″ hydrocinnamoyl ester and lacks the C4′-OH of the sphingoid base. Using a combination of in vitro studies and in vivo analysis with wild-type and partially humanized mice, it was found that the dual modifications in AH10-7 led to preservation of substantial potency in both mouse and human models of iNKT cell activation while maintaining the Th1-biasing property of other sphinganine derivatives. Structural studies by X-ray crystallography and in silico modeling provided a mechanistic basis for the effect of the C6″ substitution on enhancing presentation of AH10-7 by human CD1d. These results, along with another recently published study of combining C6″ substitutions with other Th1-biasing modifications, provide a rare example of two separate glycolipid modifications that synergize to create an analog of KRN7000 with potentially useful properties, suggesting a new approach to rational design of iNKT cell T cell receptor (TCR) ligands.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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