Anti-Trh4 T cell receptor (LnB5), pCDTCR1(TCR-C253Z)

The vector of anti-Trh4 T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse Trh4. The T cells are genetically modified through transduction with a lentiviral vector expressing Trh4-specific T cell receptor. And the vector product was designed for the treatment of Cancer.


Details


Target
Trh4
Target Species
Mouse
Epitope
MCLRMTAVM
Format
Non-modified
HLA
H-2Db
Targeting Diseases
Cancer
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
LnB5
Antibody Host
Mouse

Target


Gene Name
ceramide synthase 5
Official Symbol
Cers5
Gene ID
UniProt ID
Synonyms
Trh4; Cers5; ceramide synthase 5
Introduction
CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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