Anti-CD20 T cell receptor (A64), pCDTCR1(TCR-C034Z)

The vector of anti-CD20 T cell receptor (TCR) is constructed for the engineering of T cell to target Human CD20. The T cells are genetically modified through transduction with a lentiviral vector expressing CD20-specific T cell receptor. And the vector product was designed for the treatment of Leukemia.


Details


Target
CD20
Target Species
Human
Epitope
SLFLGILSV
Format
Soluble T-cell receptor
HLA
HLA-A2
Targeting Diseases
Autoimmune disease
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
A64
Antibody Host
Human

Target


Gene Name
membrane-spanning 4-domains, subfamily A, member 1
Official Symbol
MS4A1
Gene ID
UniProt ID
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; Chronic lymphocytic leukemia; CLL; leukemia; scFv; FcεRIγ; Chimeric antigen receptor; NK cell; Retrovirus; CARs; Lentivirus; chimeric NK cell receptors; chimeric immunoreceptors; chimeric antigen receptors; rituximab
Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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