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Anti-Peptide ANF T cell receptor (BM3.3), pCDTCR1 (TCR-YC0881)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Consistent with the view that these two polymorphic MHC residues affect peptide-binding preference, identification of the endogenous peptide (pBM8: SQYYYNSL) recognized by the BM3.3 TCR in the context of H-2Kbm8 showed that its anchor residues differed from the ones found in pBM1 and VSV8 sequences. Moreover, further comparison of the pBM8 sequence with that of pBM1 (INFDFNTI) and VSV8 (RGYVYQGL) revealed a single homologous TCR-exposed residue at P6. In contrast, the two other TCR-exposed residues found in the three peptides recognized by BM3.3 showed non-conservative substitutions.

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Details

  • Target
  • Peptide ANF
  • Epitope
  • ANFDFNTI
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Kb
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • BM3.3
  • Host Species
  • Mouse

Target

  • Introduction
  • Many T cell receptors (TCRs) that are selected to respond to foreign peptide antigens bound to self major histocompatibility complex (MHC) molecules are also reactive with allelic variants of self-MHC molecules. This property, termed alloreactivity, causes graft rejection and graft-versus-host disease.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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