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anti-tuberculosis antigen TCR, pCDTCR1 (TCR-L114Z)

The vector of anti-tuberculosis antigen T cell receptor (TCR) is constructed for the engineering of T cell to target T. bacillus tuberculosis antigen. The T cells are genetically modified through transduction with a retroviral vector expressing tuberculosis antigen-specific T cell receptor. And the vector product was designed for the treatment of tuberculosis.

Details

  • Target
  • tuberculosis antigen
  • Target Species
  • T. bacillus
  • Targeting Diseases
  • Tuberculosis
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Gene Name
  • Mycobacterium tuberculosis
  • Official Symbol
  • M. tuberculosis
  • Synonyms
  • ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
  • Introduction
  • Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of most cases of tuberculosis.[2] First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface (primarily due to the presence of mycolic acid), which makes the cells impervious to Gram staining; M. tuberculosis can appear Gram negative and Gram positive in clinical settings.[3] The Ziehl-Neelsen stain, or acid-fast stain, is used instead. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the tuberculin skin test, acid-fast stain, and chest radiographs.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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