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Anti-Peptide SQY T cell receptor ((BM3.3)-9), pCDTCR1 (TCR-YC0966)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Consistent with the view that these two polymorphic MHC residues affect peptide-binding preference, identification of the endogenous peptide (pBM8: SQYYYNSL) recognized by the BM3.3 TCR in the context of H-2Kbm8 showed that its anchor residues differed from the ones found in pBM1 and VSV8 sequences. Moreover, further comparison of the pBM8 sequence with that of pBM1 (INFDFNTI) and VSV8 (RGYVYQGL) revealed a single homologous TCR-exposed residue at P6. In contrast, the two other TCR-exposed residues found in the three peptides recognized by BM3.3 showed non-conservative substitutions.

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Details

  • Target
  • Peptide SQY
  • Epitope
  • SQYVYNSL
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Kb Y22F, M23I, E24S, D30N mutant
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • BM3.3
  • Host Species
  • Mouse

Target

  • Introduction
  • The recognition by T-cell antigen receptors (TCR) of antigenic peptides (p) bound to major histocompatibility complex (MHC)-encoded molecules is the basis of adaptive immune responses. During intrathymic differentiation, the genes encoding the variable (V) domain of the TCRα- and β-chains are assembled by site-specific DNA recombination reactions that result in the random recombination of V, diversity (D), and joining (J) gene segments. It has been argued that each clonally distributed TCR needs to cross-react with structurally distinct pMHC ligands. This property, called TCR degeneracy, is thought to permit the recognition by the whole TCR repertoire of a universe of potential antigenic peptides estimated to be much larger than the number of T-cell clones contained in an individual at a given moment. To differentiate in the thymus and, once mature, to achieve maximal sensitivity upon recognition of peptides of foreign origin, T cells also need to recognize, with low affinity, MHC molecules bearing peptides derived from self-proteins. Therefore, binding degeneracy constitutes an important TCR property.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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