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Anti-MPZ TCR, pLXSN (TCR-L075)

The vector of anti-MPZ T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse MPZ. The T cells are genetically modified through transduction with a retroviral vector expressing MPZ-specific T cell receptor. And the vector product was designed for the treatment of autoimmune peripheral neuropathy.

Details

  • Target
  • MPZ
  • Target Species
  • Mouse
  • Format
  • Non-modified TCR
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Autoimmune peripheral neuropathy
  • Vector Name
  • pLXSN
  • Vector Length
  • 6714-6688bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • myelin protein zero
  • Official Symbol
  • MPZ
  • Synonyms
  • HIV Nef; Human Immunodeficiency Viruse Nef; Human Immunodeficiency Viruse; HIV Nef protein; HIV Nef-protein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector
    ; AIDS; HIV
  • Introduction
  • This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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