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FITC-labeled Human BCMA CAR Detection Reagent, His Tag (CARD-LX001)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. FITC-labeled Human BCMA CAR Detection Reagent, His Tag is a special detection reagent which carries a polyhistidine tag at the C-terminus, and is used to detect human BCMA CAR related to the study of Multiple myeloma, leukemia, B-Cell lymphoma.

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Specifications

  • Target
  • BCMA
  • Application
  • FC
  • Purity
  • >90%
  • Endotoxin Level
  • Less than 1.0 EU per μg by the LAL method.
  • Storage
  • For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    Please protect from light and avoid repeated freeze-thaw cycles.
  • Application Notes
  • The optimal working dilutions should be determined by the end user.
  • Diseases
  • Multiple myeloma, leukemia, B-Cell lymphoma
  • Molecular Characterization
  • It contains AA Met 1 - Ala 54 (Accession # Q02223-1). It is the FITC labeled form of Human BCMA, His Tag.
  • Conjugation
  • FITC
  • Tag
  • His Tag
  • Size
  • 0.2 mg
  • Formulation
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
  • Expression
  • Human HEK293 cells
  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Form
  • Lyophilized
  • Images
  • Figure 1 Structure

Target

  • Target Introduction
  • Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
  • Target Alternative Names
  • TNF receptor superfamily member 17

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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