Carbonic anhydrase IX (CA9)

Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene. CAIX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma(ccRCC), but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. CAIX is also the most widely expressed gene in response to hypoxia. Its crucial role in intracellular pH maintenance represents the means by which cancer cells adapt to the toxic conditions of the extracellular milieu. Furthermore, the activity of CA IX stimulates the migratory pathways of cancer cells and is connected with the increase of the aggressive/invasive phenotype of tumors. CA IX expression in many types of tumors indicates its relevance as a general marker of tumor hypoxia. Moreover, its expression is closely related to prognosis of the clinical outcome in several tumor types. All above mentioned facts support the strong position of CA IX as a potential drug therapy target.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ201 T cell First G36 ~8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-MZ202 T cell Second G36 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ203 T cell Second G36 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ204 T cell Third G36 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-MZ205 T cell Third G36 ~8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CAR-T-1-L404-2 T cell First 8kb Lentiviral scFv-CD28 Humanized Inquiry
CAR-T-1-L404-G T cell First 8kb Lentiviral scFv-FcεRIγ Humanized Inquiry
CAR-T-1-L404-Z T cell First 8kb Lentiviral scFv-CD3ζ Humanized Inquiry
CAR-T-1-M305-2 T cell First G250 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M305-G T cell First G250 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M305-Z T cell First G250 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L404-2G T cell Second 8kb Lentiviral scFv-CD28-FcεRIγ Humanized Inquiry
CAR-T-2-L404-2Z T cell Second 8kb Lentiviral scFv-CD28-CD3ζ Humanized Inquiry
CAR-T-2-L404-4G T cell Second 8kb Lentiviral scFv-CD4-FcεRIγ Humanized Inquiry
CAR-T-2-L404-4Z T cell Second 8kb Lentiviral scFv-CD4-CD3ζ Humanized Inquiry
CAR-T-2-L404-8Z T cell Second 8kb Lentiviral scFv-CD8-CD3ζ Humanized Inquiry
CAR-T-2-L404-BZ T cell Second 8kb Lentiviral scFv-41BB-CD3ζ Humanized Inquiry
CAR-T-2-L404-CZ T cell Second 8kb Lentiviral scFv-b2c-CD3ζ Humanized Inquiry
CAR-T-2-M305-2G T cell Second G250 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M305-2Z T cell Second G250 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M305-4G T cell Second G250 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M305-4Z T cell Second G250 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M305-8Z T cell Second G250 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M305-BZ T cell Second G250 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M305-CZ T cell Second G250 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L404-2BZ T cell Third 8kb Lentiviral scFv-CD28-41BB-CD3ζ Humanized Inquiry
CAR-T-3-L404-2XZ T cell Third 8kb Lentiviral scFv-CD28-OX40-CD3ζ Humanized Inquiry
CAR-T-3-M305-2BZ T cell Third G250 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M305-2XZ T cell Third G250 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC49 G250 Lentivirus First scFv (G250)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC50 G250 Lentivirus First scFv (G250)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC51 G250 Lentivirus First scFv (G250)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC52 G250 Lentivirus Second scFv (G250)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC53 G250 Lentivirus Second scFv (G250)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC54 G250 Lentivirus Second scFv (G250)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC55 G250 Lentivirus Second scFv (G250)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC56 G250 Lentivirus Second scFv (G250)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC57 G250 Lentivirus Second scFv (G250)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC58 G250 Lentivirus Second scFv (G250)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC59 G250 Lentivirus Third scFv (G250)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC60 G250 Lentivirus Third scFv (G250)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC890 G36 Lentivirus First scFv (G36)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC891 G36 Lentivirus Second scFv (G36)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC892 G36 Lentivirus Second scFv (G36)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC893 G36 Lentivirus Third scFv (G36)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC894 G36 Lentivirus Third scFv (G36)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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