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Carbonic anhydrase IX (CA9)

Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene. CAIX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma(ccRCC), but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. CAIX is also the most widely expressed gene in response to hypoxia. Its crucial role in intracellular pH maintenance represents the means by which cancer cells adapt to the toxic conditions of the extracellular milieu. Furthermore, the activity of CA IX stimulates the migratory pathways of cancer cells and is connected with the increase of the aggressive/invasive phenotype of tumors. CA IX expression in many types of tumors indicates its relevance as a general marker of tumor hypoxia. Moreover, its expression is closely related to prognosis of the clinical outcome in several tumor types. All above mentioned facts support the strong position of CA IX as a potential drug therapy target.

Associated Disease
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-M305-2 Anti-CAIX scFv h(CD28) CART, pCDCAR1 Human G250 Mouse scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M305-G Anti-CAIX scFv h(FcεRIγ) CART, pCDCAR1 Human G250 Mouse scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M305-Z Anti-CAIX scFv h(CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-2G Anti-CAIX scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human G250 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-2Z Anti-CAIX scFv h(CD28-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-4G Anti-CAIX scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human G250 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-4Z Anti-CAIX scFv h(CD4-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-8Z Anti-CAIX scFv h(CD8-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-BZ Anti-CAIX scFv h(41BB-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M305-CZ Anti-CAIX scFv h(b2c-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M305-2BZ Anti-CAIX scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-BZ G250 h(41BB-CD3ζ) CAR, [T] Human Humanized scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-CZ G250 h(b2c-CD3ζ) CAR, [T] Human Humanized scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L404-2BZ G250 h(CD28-41BB-CD3ζ) CAR, [T] Human Humanized scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-2Z G250 h(CD28-CD3ζ) CAR, [T] Human Humanized scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-2G G250 h(CD28-FcεRIγ) CAR, [T] Human Humanized scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L404-2XZ G250 h(CD28-OX40-CD3ζ) CAR, [T] Human Humanized scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L404-Z G250 h(CD3ζ) CAR, [T] Human Humanized scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-4Z G250 h(CD4-CD3ζ) CAR, [T] Human Humanized scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-4G G250 h(CD4-FcεRIγ) CAR, [T] Human Humanized scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L404-8Z G250 h(CD8-CD3ζ) CAR, [T] Human Humanized scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L404-G G250 h(FcεRIγ) CAR, [T] Human Humanized scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L404-2 G250 h(CD28) CAR, [T] Human Humanized scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ201 Anti-CAIX (G36) h(CD3ζ) CAR, pCDCAR1 Human G36 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ202 Anti-CAIX (G36) h(CD28-CD3ζ) CAR, pCDCAR1 Human G36 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ203 Anti-CAIX (G36) h(41BB-CD3ζ) CAR, pCDCAR1 Human G36 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ204 Anti-CAIX (G36) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human G36 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ205 Anti-CAIX (G36) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Human G36 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M305-2XZ Anti-CAIX scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human G250 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet

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