pCDCAR1 CAIX h(28), T(CAR-T-1-M305-2)
The vector of anti-CAIX chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CAIX. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CAIX antibody linked to CD28 signaling domains. And the vector product was designed for the treatment of renal cell carcinoma (RCC).
Carbonic anhydrase IX (CA9)
Targeting Cell Type
Renal cell carcinoma (RCC)
Discription of Signaling Cassetes
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
carbonic anhydrase IX
CA9; carbonic anhydrase IX; MN; CAIX; CAIX-expressing metastatic renal cell carcinoma; renal cell carcinoma; RCC; metastatic renal cell carcinoma; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; G250
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
||G250 h(CD28-FcεRIγ) CAR, [T]
||Anti-CAIX scFv h(CD4-FcεRIγ) CART, pCDCAR1
||Anti-CAIX scFv h(CD28-FcεRIγ) CART, pCDCAR1
||Anti-CAIX scFv h(b2c-CD3ζ) CART, pCDCAR1
||G250 h(CD8-CD3ζ) CAR, [T]
||G250 h(41BB-CD3ζ) CAR, [T]
||Lenti-Carbonic anhydrase IX (CA9) CAR (scFv-41BB-CD3ζ, G36) Viral Particle
||Anti-CAIX scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1
||Anti-CAIX scFv h(41BB-CD3ζ) CART, pCDCAR1
||Anti-CAIX (G36) h(CD28-41BB-CD3ζ) CAR, pCDCAR1