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FCRL1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Product List Background Anti-FCRL1 CAR-T Services Anti-FCRL1 CAR-T In Vitro Assay Services Anti-FCRL1 CAR-T In Vivo Assay Services

Product List

At Creative Biolabs, we offer various anti-FCRL1 CAR products that are designed to target FCRL1-expressing malignancies with high specificity and efficacy. Our comprehensive range of anti-FCRL1 CAR products includes CAR vectors, CAR mRNA, and CAR cells, all aimed at providing innovative immune cell therapies for the treatment of FCRL1-associated diseases.

Background

Fc receptor-like 1 (FCRL1) is a cell surface protein that belongs to the immunoglobulin superfamily. It is a member of the Fc receptor-like family of proteins, which are involved in the regulation of immune responses. FCRL1 is primarily expressed on the surface of B cells and subsets of T cells, and plays a role in modulating immune signaling pathways. It has been suggested that FCRL1 may function as an inhibitory receptor, modulating the activity of other immune receptors and dampening immune responses. FCRL1 has been implicated in various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, as well as in certain types of cancer. By targeting FCRL1, researchers hope to regulate aberrant immune responses and potentially improve outcomes for patients with autoimmune diseases or cancer.

Fig.1 Schematic of the FCRL family of proteins. (Capone, et al., 2023)

Fig.1 Schematic of the FCRL family of proteins.1

Associated Disease

  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Lymphomas
  • Leukemias

Anti-FCRL1 CAR-T Services

Anti-FCRL1 CAR-T In Vitro Assays

Creative Biolabs offers comprehensive in vitro assays to assess the efficacy and safety of anti-FCRL1 CAR-T cell therapy, including:

We provide several anti-FCRL1 CAR-T expression tests including WB, FCM, and RT-PCR. These tests are designed to analyze different aspects of the expression and functionality of FCRL1-targeting CAR-T cells

The CAR-T proliferation test specifically focuses on measuring the proliferation capacity of CAR-T cells, which refers to their ability to grow and expand in response to a specific antigen target. Our experts utilize various assays and techniques to assess the rate of cell growth and expansion of CAR-T cells in response to the targeted antigen stimulation

At our labs, our cytokine release tests typically measure the levels of various cytokines, such as interferon-gamma, interleukin-2, interleukin-6, and tumor necrosis factor-alpha, in the supernatant of cell cultures containing the CAR T cells and target cancer cells. Elevated levels of cytokines in this test can indicate that the CAR T cells are actively recognizing and attacking the cancer cells.

In vitro CAR-T cell cytotoxicity assays are valuable tools for evaluating the killing potential of CAR-T cells and optimizing their therapeutic efficacy for the treatment of cancer and other diseases. Our team offers several types of in vitro cytotoxicity assays that can be used depending on the specific research question and the type of cells being studied, including imaging-based assays, chromium release assay, and LDH release assay.

Anti-FCRL1 CAR-T In Vivo Assays

CAR-T in vivo assays are tests used to evaluate the effectiveness of CAR-T cell therapies in living organisms, typically in animal models like mice. We provide various assays that involve injecting the CAR-T cells into the animal models and monitoring their ability to target and kill cancer cells or other target cells expressing the specific antigen.

Reference

  1. Capone, Mollie, et al. "Fc receptor-like proteins in pathophysiology of B-cell disorder." Journal of clinical & cellular immunology 7.3 (2016).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-0120ZP1815 Anti-FCRL1 (XHM398) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM398 Human scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1816 Anti-FCRL1 (XHM398) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human XHM398 Human scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1817 Anti-FCRL1 (XHM399) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM399 Human scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1818 Anti-FCRL1 (XHM399) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human XHM399 Human scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1819 Anti-FCRL1 (XHM400) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM400 Human scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1820 Anti-FCRL1 (XHM400) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human XHM400 Human scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1821 Anti-FCRL1 (CBXC-0848) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0848 Human scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1822 Anti-FCRL1 (CBXC-0848) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0848 Human scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1823 Anti-FCRL1 (7H13) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 7H13 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1824 Anti-FCRL1 (7H13) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse 7H13 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1825 Anti-FCRL1 (CBXF-1735) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXF-1735 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1826 Anti-FCRL1 (CBXF-1735) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXF-1735 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1827 Anti-FCRL1 (CBXF-1734) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXF-1734 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1828 Anti-FCRL1 (CBXF-1734) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXF-1734 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1829 Anti-FCRL1 (CBXF-0480) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXF-0480 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1830 Anti-FCRL1 (CBXF-0480) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXF-0480 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1831 Anti-FCRL1 (CBXF-2593) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBXF-2593 Mouse scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0120ZP1832 Anti-FCRL1 (CBXF-2593) h(4-1BB-CD3ζ) CAR, pCDCAR1 Mouse CBXF-2593 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-0622-ZP3272 Anti-FCRL1 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 Human VHH1-VHH2-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-0622-ZP3444 Anti-FCRL1 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 VHH1-VHH2-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
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