HER2

Human epidermal growth factor receptor 2 (HER2), also known as ErbB-2, cluster of differentiation 340 (CD340), proto-oncogene Neu, is encoded by the ERBB2 gene. As a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family, HER2 has become an important biomarker and target of therapy for breast cancer. Not only the overexpression of HER2 occurs in breast cancer, but also it is strongly associated with the ovarian cancer, stomach cancer, lung adenocarcinoma, uterine cancer, salivary gland cancer, acute lymphoblastic leukemia (ALL), bladder cancer, childhood medulloblastoma, colorectal cancer, oral squamous cell carcinoma, germ-cell testicular tumor, cholangiocarcinoma, osteosarcoma, pancreatic adenocarcinoma and prostate cancer.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC172 T cell Second 4D5 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC188 T cell Third Trastuzumab ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC252 T cell Third 6D ~8kb Nonviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC253 T cell Third 7G ~8kb Nonviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC366 T cell Third Trastuzumab ~8kb Lentiviral Human Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C097Z HER2 Human HER2-1 Murinized ~8kb Lentiviral KIFGSLAFL Codon-optimized and murinized HLA-A2 Inquiry
TCR-C098Z HER2 Human HER2-2 Murinized ~8kb Lentiviral KIFGSLAFL Codon-optimized and murinized HLA-A2 Inquiry
TCR-C099Z HER2 Human HER2-3 Murinized ~8kb Lentiviral KIFGSLAFL Codon-optimized and murinized HLA-A2 Inquiry
TCR-C100Z HER2 Human HER2-4 Murinized ~8kb Lentiviral KIFGSLAFL Codon-optimized and murinized HLA-A2 Inquiry
TCR-C101Z HER2 Human Human ~8kb Lentiviral TYLPTNASL Non-modified HLA-A2 Inquiry
TCR-L049Z HER2 Human Human 8kb Lentiviral ErbB2 369–377 Non-modified HLA-A2 Inquiry
TCR-L050 HER2 Human Human 6700bp retroviral vector ErbB2 369–377 Non-modified TCR HLA-A2 Inquiry
TCR-L050Z HER2 Human Human 8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L051 HER2 Human Human 3817bp retroviral vector KIFGSLAFL Non-modified TCR HLA-A2 Inquiry
TCR-L221 Her2 Human A2 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L222 Her2 Human A3 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L223 Her2 Human B7 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L224 Her2 Human B10 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L225 Her2 Human D1 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L226 Her2 Human E1 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L227 Her2 Human E2 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L228 Her2 Human G3 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L229 Her2 Human G8 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L230 Her2 Human H3 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry
TCR-L231 Her2 Human H5 Human ~8kb Lentiviral KIFGSLAFL Non-modified HLA-A2 Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC655 4D5 Lentivirus Second scFv (4D5)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC667 Lentivirus Second scFv-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC724 6D Lentivirus Third scFv (6D)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC725 7G Lentivirus Third scFv (7G)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C127 Human HER2-1 Murinized Lentivirus KIFGSLAFL Codon-optimized and murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C128 Human Human Lentivirus TYLPTNASL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C129 Human A2 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C130 Human A3 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C131 Human B7 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C132 Human B10 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C133 Human D1 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C134 Human E1 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C135 Human E2 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C136 Human G3 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C137 Human G8 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C138 Human H3 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C139 Human H5 Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C140 Human Human Lentivirus KIFGSLAFL Non-modified TCR > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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