Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Human epidermal growth factor receptor 2 (HER2), also known as ErbB-2, cluster of differentiation 340 (CD340), proto-oncogene Neu, is encoded by the ERBB2 gene. As a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family, HER2 has become an important biomarker and target of therapy for breast cancer. Not only the overexpression of HER2 occurs in breast cancer, but also it is strongly associated with the ovarian cancer, stomach cancer, lung adenocarcinoma, uterine cancer, salivary gland cancer, acute lymphoblastic leukemia (ALL), bladder cancer, childhood medulloblastoma, colorectal cancer, oral squamous cell carcinoma, germ-cell testicular tumor, cholangiocarcinoma, osteosarcoma, pancreatic adenocarcinoma and prostate cancer.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-ZP8468 | A uniCAR [Anti-FITC CAR], with a Fab-based CAR Adaptor [Anti-Her2 (Trastuzumab(4D5))], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8477 | A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-Her2 (Trastuzumab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8487 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-Her2 (Trastuzumab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8502 | A uniCAR [Anti-leucine zipper CAR], with a mAb-based CAR Adaptor [Anti-Her2], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-MV-01LX020 | Anti-HER2 (NY29) h(CD28-CD3ζ) CAR, pMMLV | Human | NY29 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX021 | Anti-HER2 (FRP5) h(CD28-CD3ζ) CAR, pMMLV | Human | FRP5 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX022 | Anti-HER2 (4D5) h(CD28-CD3ζ) CAR, pMMLV | Human | 4D5 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX023 | Anti-HER2 (ICR12) h(CD28-CD3ζ) CAR, pMMLV | Human | ICR12 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX265 | Anti-HER2 (NY29) h(41BB-CD3ζ) CAR, pMMLV | Human | NY29 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX266 | Anti-HER2 (FRP5) h(41BB-CD3ζ) CAR, pMMLV | Human | FRP5 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX267 | Anti-HER2 (4D5) h(41BB-CD3ζ) CAR, pMMLV | Human | 4D5 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX268 | Anti-HER2 (ICR12) h(41BB-CD3ζ) CAR, pMMLV | Human | ICR12 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-SB-02LX019 | Anti-HER2 (NY29) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | NY29 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX020 | Anti-HER2 (FRP5) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | FRP5 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX021 | Anti-HER2 (4D5) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | 4D5 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX022 | Anti-HER2 (ICR12) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | ICR12 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX261 | Anti-HER2 (NY29) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | NY29 | Mouse | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX503 | Anti-HER2 (NY29) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | NY29 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX504 | Anti-HER2 (FRP5) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | FRP5 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| XS-0722-YF343 | TS-IL15 SA Anti-Human HER2 scFv (OTI5C4) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | OTI5C4 | Mouse | 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF344 | TS-IL15 SA Anti-Human HER2 scFv (4D5) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | 4D5 | Mouse | 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF462 | TS-NKG2DL Anti-hCD3 and Anti-Human HER2 scFv (Trastuzumab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Trastuzumab | Humanized | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF463 | TS-NKG2DL Anti-hCD3 and Anti-Human HER2 scFv (OTI5C4) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | OTI5C4 | Mouse | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF522 | TS-NKG2DL Anti-hCD3 and Anti-Human HER2 scFv (Trastuzumab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Trastuzumab | Humanized | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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