Biotinylated Human HER2 CAR Detection Reagent, His & Avi Tag (CARD-LX032)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Biotinylated Human HER2 CAR Detection Reagent, His & Avi Tag is a special detection reagent which carries a polyhistidine tag at the C-terminus, followed by an Avi tag, and is used to detect human HER2 CAR related to the study of Ovarian cancer, breast cancer, glioblastoma, osteosarcoma.

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Specifications

Target
HER2

Application
ELISA, FC

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -42°C or lower.
Please avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Ovarian cancer, breast cancer, glioblastoma, osteosarcoma

Molecular Characterization
It contains AA Thr 23 - Thr 652 (Accession # P04626-1).

Conjugation
Biotin

Tag
His & Avi Tag

Size
0.2 mg

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Images
Figure 1 Structure

Target

Target Introduction
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

Target Alternative Names
erb-b2 receptor tyrosine kinase 2

Entrez Gene ID
2064

UniProt ID
P04626-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.