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Anti-5OH-DF T cell receptor (A-F7), pCDTCR1 (TCR-YC0043)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-5OH-DF T cell receptor (TCR) is constructed for the engineering of T cell to target 5OH-DF (5-hydroxydiclofenac) restricted by human MR1. The T cells are genetically modified through transduction with a lentiviral vector expressing 5OH-DF-specific T cell receptor.

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Details

  • Target
  • 5OH-DF
  • Epitope
  • 5-hydroxydiclofenac
  • Format
  • Non-Modified TCR
  • Allele
  • human MR1
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • A-F7
  • Host Species
  • Human

Target

  • Introduction
  • Diclofenac (DF) is one of the most popular drugs world-wide belonging to the family of nonsteroidal antiinflammatory drugs (NSAIDs). Adverse drug reactions (ADRs), which occur in about every fifth patient, are well-known side effects mainly caused by the NSAIDs' acidic properties. More serious are drug hypersensitivity reactions (DHRs) to DF, which clinically manifest as Type-I-like allergic reactions with sudden and unpredictable occurrence and can progress into anaphylactic shock. Two pathomechanisms are currently thought to be involved in NSAIDs hypersensitivity reactions: (i) multiple NSAIDs hypersensitivity (also those involving DF) has been considered as pharmacokinetic disorders due to non-selective coinhibition of cyclooxygenase (COX)-1 leading to shifts in the prostaglandin and leukotriene levels; (ii) in contrast, for selective NSAID hypersensitivities including DF, an involvement of the immune system is still being postulated.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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