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Anti-C48H93NO11S T cell receptor (XV19), pCDTCR1 (TCR-YC0241)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The XV19 TCR did not bind CD1d–α-GalCer but showed approximately equivalent affinity for the two CD1d-sulfatide antigens C24:1 sulfatide and C24:0 sulfatide. This indicated that the different reactivity of the XV19 NKT cell hybridoma to different forms of sulfatide antigens was more attributable to loading and antigen-presentation mechanisms, analogous to the reactivity of type I NKT cells to lipid-based antigens with modifications in their acyl chains. The micromolar affinity of the XV19 TCR–CD1d-sulfatide interaction was in contrast to the nanomolar affinity of type I NKT cell TCRs for CD1d–α-GalCer and was more similar to the affinity of autoreactive type I NKT cell TCRs for β-linked self antigens such as β-GalCer and iGb3 and was also in the range typically associated with the recognition of complexes of peptide and major histocompatibility complex class I by TCRs.

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Details

  • Target
  • C48H93NO11S
  • Target Species
  • Cattle
  • Epitope
  • 1-(3-O-sulfo-beta-D-galactosyl)-N-tetracosanoylsphingosine
  • Format
  • Non-Modified TCR
  • Allele
  • mouse CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • XV19
  • Host Species
  • Mouse

Target

  • Introduction
  • 1-(3-O-sulfo-beta-D-galactosyl)-N-tetracosanoylsphingosine is a D-galactosyl-N-acylsphingosine having a sulfo group at the 3-position on the galactose ring and tetracosanoyl as the N-acyl group. It is a galactosylceramide sulfate and a N-acyl-beta-D-galactosylsphingosine. It is a conjugate acid of a 1-(3-O-sulfo-beta-D-galactosyl)-N-tetracosanoylsphingosine(1-).

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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