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Anti-LMP2 T cell receptor (PL5.05), pCDTCR1 (TCR-C110Z)

The vector of anti-LMP2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV LMP2. The T cells are genetically modified through transduction with a lentiviral vector expressing LMP2-specific T cell receptor. And the vector product was designed for the treatment of Hodgkin's disease.

Details

  • Target
  • LMP2
  • Target Species
  • EBV
  • Epitope
  • CLGGLLTMV
  • Format
  • Non-modified
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Hodgkin's disease
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • PL5.05
  • Antibody Host
  • Human

Target

  • Gene Name
  • EBNA3A nuclear protein
  • Official Symbol
  • LMP2
  • Synonyms
  • CT1.10; MAGE10; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
  • Introduction
  • Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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