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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The M33.64 cell line was activated in response to 5-OP-RU and E. coli but also exhibited robust, MR1-dependent activation in the absence of added Ag, consistent with it being stained with empty MR1 tetramer. The MAV36 TCR+ cells were activated when co-cultured with C1R.MR1 cells in the presence of E. coli or 5-OP-RU, but showed little response without added Ag. To further investigate the M33.64 TCR autoreactivity, the M33.64 TCR+ cell line was co-cultured with MR1-transduced C1R cells that were flow cytometrically sorted based on graded MR1 expression. The M33.64 TCR+ cells upregulated CD69 in an MR1-dose-dependent manner, without added Ag, confirming that in contrast to other MAIT TCRs, the M33.64 TCR is MR1 autoreactive.
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