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Anti-nef T cell receptor (HIV-B8-FL8-2), pCDTCR1 (TCR-L328)

The vector of anti-nef T cell receptor (TCR) is constructed for the engineering of T cell to target HIV-l nef. The T cells are genetically modified through transduction with a lentiviral vector expressing nef-specific T cell receptor. And the vector product was designed for the treatment of HIV infection.

Details

  • Target
  • Nef
  • Target Species
  • HIV-l
  • Epitope
  • FLKEKGGL
  • Format
  • Non-modified
  • HLA
  • HLA-B8
  • Targeting Diseases
  • HIV infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • HIV-B8-FL8-2
  • Antibody Host
  • Human

Target

  • Gene Name
  • Nef
  • Official Symbol
  • nef
  • Synonyms
  • HIV Nef; Human Immunodeficiency Viruse Nef; Human Immunodeficiency Viruse; HIV Nef protein; HIV Nef-protein
  • Introduction
  • Nef (Negative Regulatory Factor) is a small 27-35 kDa myristoylated protein encoded by primate lentiviruses. These include Human Immunodeficiency Viruses (HIV-1 and HIV-2) and Simian Immunodeficiency Virus (SIV). Nef localizes primarily to the cytoplasm but also partially to the Plasma Membrane (PM) and is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen. Nef stands for "Negative Factor" and although it is often considered dispensable for HIV-1 replication, in infected hosts the viral protein markedly elevates viral titers.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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