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Anti-MBP T cell receptor ((Hy.1B11)-7), pCDTCR1 (TCR-YC0667)

The Hy.1B11 TCR recognizes the MBP (85-99) peptide bound in the same register to DQ1. This TCR has a higher affinity for its pMHC target than the previously crystallized self-reactive TCRs Ob.1A12 and 3A6. However, the Hy.1B11 TCR is HLA-DQ restricted, whereas the other two TCRs are HLA-DR restricted. HLA-DQ molecules are expressed at ∼10-fold lower levels than HLA-DR molecules, and the higher affinity of Hy.1B11 TCR may therefore be required for this TCR to adequately respond to the self-peptide on peripheral antigen-presenting cells. HLA-DQ molecules are expressed at very low levels in the medulla of the thymus, which may have facilitated escape of negative selection by the Hy.1B11 T cell. It is also possible that the tilted binding mode of Hy.1B11 TCR binding affects formation of higher order structures among TCRs and/or other proteins involved in T cell activation at the immunological synapse.

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Details

  • Target
  • MBP
  • Epitope
  • ENPVVHFFKAIVTPR
  • Format
  • Non-Modified TCR
  • HLA
  • HLA class II
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Hy.1B11
  • TCR Host Animal
  • Human

Target

  • Introduction
  • Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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