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Anti-NY-ESO-1 T cell receptor (KFJ5), pCDTCR1 (TCR-YC0772)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Interestingly, the tolerance of KFJ5 and KFJ37 T-cell clones towards the P3-Arg mutation differed, with KFJ37 retaining ~90% of reactivity, whereas KFJ5 reactivity was completely ablated, suggesting that the KFJ5 and KFJ37 TCRs focused on the central region of the NY-ESO-1 (60–72) peptide presented by HLA-B*07:02 with differing fine specificities.

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Details

  • Target
  • NY-ESO-1
  • Target Species
  • Human
  • Epitope
  • APRGPHGGAASGL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-B*07:02
  • Targeting Diseases
  • Melanoma, Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • KFJ5
  • Host Species
  • Human

Target

  • Introduction
  • The highly homologous NY-ESO-1 and LAGE-1 proteins are germ cell Ags of unknown function, which are frequently expressed in a variety of tumors including melanoma, breast cancer and, most prominently, myeloma. NYESO-1 and LAGE-1 are highly immunogenic, and CTL responses to an immunodominant, HLA-A2-restricted NY-ESO-1/LAGE- 1157–165 epitope (SLLMWITQC) can commonly be detected in cancer patients. There has thus been a major focus on NYESO-1/LAGE-1 as candidates for the development of immunotherapeutic cancer vaccination.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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